Monday, May 29th, 2017 - Riddhiman Kannan uses humanized yeast to study evolution and disease!

29May

Did you know that allthough Saccharomyces cerevisiae (Baker’s yeast) and Homo sapiens (humans, us) are separated by a billion years in evolutionary time, nearly half (~47%) of the essential yeast genes can be substituted for by their corresponding human counterparts and the yeast are just fine?! On this episode, Riddhiman Kannan talks to us about how putting human genes into yeast can be used as a tool to more easily study human evolution and disease, and even help discover new therapies!

*NOTE* The recording of the interview comes in a few minutes after we actually started; sorry for the missing time!

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Monday, May 8th, 2017 - Stephen Jones talks about cellular aging!

8May

What is aging? How old you are, or maybe instead how well you maintain your health? Where does aging occur? In our organs, tissues, or even individual cells? These answers to these seemingly simple questions, are anything but. In this episode, Stephen Jones tells us how his study of individual cells using a "microfluidic" machine allows him to capture about a thousand individual cells at a time and watch them over their entire lives through each (division) replication, conflict, and catastrophe, thereby directly observing the cellular aging process. Using this work has allowed him to also shed light on the processes of cellular quiescence (taking a "break" from division) and silencing (how cells keep some parts of their DNA shut off), so we can understand how these vital cellular functions contribute to the aging process!

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